منابع مشابه
Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks
How the cholinergic and dopaminergic systems of the striatum interact and how these interface with the massive neocortical input to the striatum are classic questions of cardinal interest to neurology and psychiatry. In this issue of Neuron, Ding and colleagues show that a key to these puzzles lies in the thalamic inputs to the striatum targeting its cholinergic interneurons.
متن کاملA Time to Pause and Reflect: When a Patient with Autoimmune Hepatitis Stops Responding to Corticosteroids
Drug-induced liver injury (DILI) with features of autoimmunity (AI) is a challenging diagnosis to make particularly due to its apparent corticosteroid responsiveness. We present the case of a 74-year-old woman who presented with a 2-week history of jaundice and fatigue. She was initially diagnosed with autoimmune hepatitis (AIH) based on biochemical and histological characteristics and prompt r...
متن کاملStem cells to insulin secreting cells: two steps forward and now a time to pause?
Two groups recently reported the in vitro differentiation of human embryonic stem cells into insulin-secreting cells, achieving an elusive goal for regenerative medicine. Herein we provide a perspective regarding these developments, compare phenotypes of the insulin-containing cells to human β cells, and discuss implications for type 1 diabetes research and clinical care.
متن کاملPause length variations within and between speakers over time
In the current study, intra-turn pause variation has been investigated within and between speakers in dialogues. Results show that there is a tendency for different speakers to prefer different pause locations within turns. There was further a significant correlation in the majority of the dialogues between how the median lengths of pauses varied for the speakers over the course of the dialogue...
متن کاملTime for a Strategic and Intellectual Pause in Afghanistan
A eight years of increasing involvement in Afghanistan, the US-led Coalition appears to be at an intellectual crossroads. Despite progress in a number of sectors, the tipping point in favor of an irreversible momentum toward functional governance remains elusive. As frustration mounts, Coalition members have become more vocal about their desire to withdraw by a certain deadline rather than seei...
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ژورنال
عنوان ژورنال: Science
سال: 1964
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.144.3624.1297